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Sebaceous epithelioma is a common new skin appearance in dogs characterized by a dominance of basalioid cells with few well differentiated sebocytes. The possibility of lymph node metastases is anecdotal and distant metastases have never been observed. A nine-year-old dachshund had a sebum epithelium of the upper lip with highly aggressive biological behaviour.

Eleven months after the removal was completed with no doubt, the dog had a local relapse and five months later metastases of the distant, lung and central nervous system were observed. According to the authors, this is the first report on a sebum epithelium that leads to the death of the animal due to metastases and confirms the need to include some of these neoplasms in the carcinoma category.

For aggressive sebum epithelia, the definition of epitheliomatous sebum cancer has been proposed although the differentiation criteria have not yet been established. A case study with 64 sebum epithelial cells showed only four remaining after surgical removal and no metastases in the regional lymph nodes. In the case described, the number of mitoses and growth fragments in the primary neoplasm was already high and similar to local recurrence and metastases, suggesting aggressiveness of the tumor at the time of its emergence.

In addition, histological examination of local recurrences and metastases showed a tendency to loss of sebum differentiation and increased evidence of tissue invasion, suggesting malignant progression of the neoplasm. The authors suggest that the surgical margins of the removed sebum epithelia should be histologically evaluated and that a new excision should be performed in case of incomplete removal.

"Bettini G, Morini M, Mandrioli L, Capitani O, Gandini G. Vet Dermatol. 2009 June 22nd. The sebum epithelium is a frequent new skin appearance in dogs, characterized by a dominance of basalioid cells with few well differentiated sebocytes. The possibility of lymph node metastases is anecdotal and distant metastases have never been observed.

A nine-year-old dachshund had a sebum epithelium of the upper lip with highly aggressive biological behaviour. Eleven months after the removal was completed with no doubt, the dog had a local relapse and five months later metastases of the distant, lung and central nervous system were observed. According to the authors, this is the first report on a sebum epithelium that leads to the death of the animal due to metastases and confirms the need to include some of these neoplasms in the carcinoma category.

For aggressive sebum epithelia, the definition of epitheliomatous sebum cancer has been proposed although the differentiation criteria have not yet been established. A case study with 64 sebum epithelial cells showed only four remaining after surgical removal and no metastases in the regional lymph nodes. In the case described, the number of mitoses and growth fragments in the primary neoplasm was already high and similar to local recurrence and metastases, suggesting aggressiveness of the tumor at the time of its emergence.

In addition, histological examination of local recurrences and metastases showed a tendency to loss of sebum differentiation and increased evidence of tissue invasion, suggesting malignant progression of the neoplasm. The authors suggest that the surgical margins of the removed sebum epithelia should be histologically evaluated and that a new excision should be performed in case of incomplete removal.

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